Resource for Integrated Glycotechnology
University of Georgia
A team of Research Resource investigators, including members of the labs of Joshua Sharp and Kelley Moremen, have worked together to help determine the role of glycosaminoglycans (GAGs) in nervous system development. GAGs bridge a complex of two proteins, Robo1 and Slit2, to help guide the development of axons in the nervous system. Using a …
Glycosaminoglycan builder provides a point-and-click interface to build custom structures for all classes of glycosaminoglycans (GAGs). The web-tool is a simple interface where the user first chooses the desired class of GAG molecule and then enters the primary sequence by clicking through the set of constituent monosaccharides. The appropriate sulfation patterns commonly observed in each …
A collaboration between UGA scientist Jonathan Amster, Robert Linhardt, at Rensselaer Polytechnic Institute, and Toshihiko Toida, at Chiba University, has led to the first ever sequencing of full length glycans from a naturally occurring proteoglycan. Although much of the structure of the protein portion of bikunin was well known, as was its homogenous N-linked glycan, …
Through a collaboration between synthetic chemists investigating chemical synthesis of defined heparan sulfate oligosaccharides (Chengli Zong, Andre Venot, and Geert-Jan Boons), analytical chemists developing a derivatization, separation, and MS/MS methods for separating and sequencing complex mixtures of heparan sulfate oligosaccharides (Rongrong Huang, Dandan Zhou, and Joshua Sharp), and a bioinformaticist developing software for high-throughput analysis …
